I am interested in understanding the molecular mechanisms underlying central nervous system dysfunctions with a particular focus on disorders associated with autism, epilepsy and intellectual disabilities. Tuberous Sclerosis Complex and CDKL5 Deficiency Disorder are genetic syndromes characterized by severe neurological symptoms and intractable seizure often arising in early childhood. I study the neuronal phenotypes of these disorders and establish image-based high content assays for phenotypic screening with primary neuronal cultures to identify novel drug targets. Primary cilia are sensory antenna protruding from the cell surface with a key role in brain homeostasis and development. Genetic deficits in ciliary signaling proteins are associated with severe neurodevelopmental disorders. My current work focuses on the role of primary cilia in these disorders using in vitro and in vivo models. My ultimate goal is to help identifying therapeutic alternative and improve the lives of the patients.