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Investigating human-specific changes that occur during early neuron development with loss of TSC2 or CDKL5
Understanding the molecular mechanisms underlying CNS dysfunctions
The role of DEPDC5 in epileptogenesis and brain malformations
Investigating the mechanism of FMRP dysregulation with loss of TSC2.
Characterization of neuropsychiatric disease phenotypes of 16p11.2 iPSC derived dopaminergic neurons and cortical neurons in vitro
Striatal Deficits in the Development of Schizophrenia in Patients with Copy Number Variations of 16p11.2.
Childhood-onset movement disorders & Hereditary Spastic Paraplegia
Development of an in vitro model of SSADH deficiency using patient iPSC derived neurons to support unbiased screening of novel therapeutic approaches to treatment
Role of Interneurons in TSC-associated epilepsy
Investigating the effects of 16p13.11 CNVs on excitatory and inhibitory neurons using iPSCs
Investigating human-specific changes that occur during early neuron development with loss of TSC2 or CDKL5
Understanding the molecular mechanisms underlying CNS dysfunctions
The role of DEPDC5 in epileptogenesis and brain malformations
Investigating the mechanism of FMRP dysregulation with loss of TSC2.
Characterization of neuropsychiatric disease phenotypes of 16p11.2 iPSC derived dopaminergic neurons and cortical neurons in vitro
Striatal Deficits in the Development of Schizophrenia in Patients with Copy Number Variations of 16p11.2.
Development of an in vitro model of SSADH deficiency using patient iPSC derived neurons to support unbiased screening of novel therapeutic approaches to treatment
Childhood-onset movement disorders & Hereditary Spastic Paraplegia
Investigating the effects of 16p13.11 CNVs on excitatory and inhibitory neurons using iPSCs
Role of Interneurons in TSC-associated epilepsy