Autistic-like behavior and cerebellar dysfunction in Purkinje cell Tsc1 mutant mice.

Autistic-like behavior and cerebellar dysfunction in Purkinje cell Tsc1 mutant mice.

Although autism spectrum disorders (ASDs) are highly prevalent, the neural circuitry underlying ASDs remains poorly understood. The cerebellum has been implicated in autism based on human studies, but mouse models that rigorously demonstrate a role for cerebellar dysfunction leading to core features of autism are lacking.

Neuronal Tsc1/2 complex controls autophagy through AMPK dependent regulation of ULK1.

Neuronal Tsc1/2 complex controls autophagy through AMPK dependent regulation of ULK1.

Autophagy is a catabolic process for the removal of damaged organelles and energy retrieval in which cytoplasmic material and damaged organelles are engulfed in double membrane vesicles and delivered to the lysosomes for degradation.

Interaction of SMN and HuD with cpg15 mRNA rescues motor neuron axonal deficits.

Interaction of SMN and HuD with cpg15 mRNA rescues motor neuron axonal deficits.

Spinal muscular atrophy (SMA) is a devastating motor neuron disease caused by mutations in the SMN1 gene. Reduced levels of SMN protein impair various aspects of neuronal development, particularly axonal growth.