mTOR'ing across the Cortex by Chopping the Cilia

Alessia Di Nardo; Mustafa Sahin

doi:10.1016/j.neuron.2018.06.042

mTOR'ing across the Cortex by Chopping the Cilia

Neuron. 2018 Jul 11;99(1):3-5. doi: 10.1016/j.neuron.2018.06.042.

Authors

Alessia Di Nardo¹, Mustafa Sahin²

Affiliations

¹ F.M. Kirby Neurobiology Center, Translational Neuroscience Center, Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
² F.M. Kirby Neurobiology Center, Translational Neuroscience Center, Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA. Electronic address: mustafa.sahin@childrens.harvard.edu.

PMID: 30001510
DOI: 10.1016/j.neuron.2018.06.042

Abstract

Somatic mutation of the MTOR gene is a genetic etiology of focal malformations of cortical development. In this issue of Neuron, Park et al. (2018) identify defective autophagy-dependent ciliogenesis/Wnt signaling as an underlying mechanism affecting neuronal migration and cortical lamination.

Publication types

Comment

MeSH terms

Brain
Cilia*
Mutation
Neurons
TOR Serine-Threonine Kinases / genetics*

Substances

TOR Serine-Threonine Kinases