Angelica D'Amore, PhD
Dr. D'Amore's research focuses on animal modeling, using CRISPR-Cas9 technology to generate disease models in zebrafish, and animal husbandry/maintenance for our TSC2 mouse-colonies. Her work is also based on in-vitro experiments, focusing on neuronal-dissociation from rodents.
- Generation and characterization of six human induced pluripotent stem cell lines (iPSC) from three families with AP4B1-associated hereditary spastic paraplegia (SPG47)
- Loss of ap4s1 in zebrafish leads to neurodevelopmental defects resembling spastic paraplegia 52
- High-throughput imaging of ATG9A distribution as a diagnostic functional assay for adaptor protein complex 4-associated hereditary spastic paraplegia
- Systematic Analysis of Brain MRI Findings in Adaptor Protein Complex 4-Associated Hereditary Spastic Paraplegia
- Defining the clinical, molecular and imaging spectrum of adaptor protein complex 4-associated hereditary spastic paraplegia
- Adaptor protein complex 4 deficiency: a paradigm of childhood-onset hereditary spastic paraplegia caused by defective protein trafficking